|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis.
|
31486669 |
2020 |
|
Idiopathic pulmonary hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, overexpression of miR-29b in normal PASMC decreased large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> (BK<sub>Ca</sub>) channel currents and downregulated BK<sub>Ca</sub> channel β1 subunit (BK<sub>Ca</sub>β1 or KCNMB1) expression, while inhibition of miR-29b in IPAH-PASMC increased BK<sub>Ca</sub> channel activity and BK<sub>Ca</sub>β1 levels.
|
31553627 |
2020 |
|
Essential Hypertension
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The dominant model of KCNJ11 E23K and KCNMB1 E65K might be susceptible factors for essential hypertension.
|
31169684 |
2019 |
|
Bacteremia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that GAS infection preferentially induces ineffective LAP to evade xenophagic killing in endothelial cells through the SLO/β1 integrin/NOX2/ROS pathway.<b>IMPORTANCE</b> Our previous reports showed that the LC3-associated GAS-containing single membrane vacuoles are inefficient for bacterial clearance in endothelial cells, which may result in bacteremia.
|
31575768 |
2019 |
|
Essential Hypertension
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genotype and allele frequency analyses revealed that the frequency of genotypes KCNJ11-rs2285676 and KCNMB1-rs11739136 was not significantly different between the EH and NT groups.
|
28962116 |
2017 |
|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
High-fat diet-induced obesity alters nitric oxide-mediated neuromuscular transmission and smooth muscle excitability in the mouse distal colon.
|
27288421 |
2016 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone.
|
25576871 |
2015 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone.
|
25576871 |
2015 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
[Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats].
|
24589593 |
2014 |
|
Insulin Resistance
|
0.200 |
Biomarker
|
phenotype |
RGD |
Reduction of large-conductance Ca²(+) -activated K(+) channel with compensatory increase of nitric oxide in insulin resistant rats.
|
21425425 |
2011 |
|
Hypertensive disease
|
0.550 |
GeneticVariation
|
group |
BEFREE |
KCNMB1 gain-of-function variant Glu65Lys results in generalized vasorelaxation and thus protection against systemic hypertension.
|
20861615 |
2010 |
|
Kidney Failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
|
20861615 |
2010 |
|
Chronic Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Common KCNMB1 gain-of-function variant Glu65Lys influences GFR, and 65Lys carriers exhibit not only elevated baseline GFR, but also more rapid GFR decline (and consequent development of renal failure) in CKD.
|
20861615 |
2010 |
|
Hypertensive disease
|
0.550 |
AlteredExpression
|
group |
LHGDN |
Maxi-K+ channel beta1 expression in sleep apnea patients and its modulation by CPAP treatment.
|
19057512 |
2009 |
|
Sleep Apnea, Obstructive
|
0.010 |
Biomarker
|
disease |
LHGDN |
Maxi-K+ channel beta1 expression in sleep apnea patients and its modulation by CPAP treatment.
|
19057512 |
2009 |
|
Hypertensive disease
|
0.550 |
GeneticVariation
|
group |
BEFREE |
We also found that the carriers of minor T allele of KCNMB1-rs11739136 had a significantly decreased risk for hypertension (TT+CT vs. CC; odds ratio=0.83; 95% confidence interval, 0.72-0.95; P value after the Bonferroni correction=0.008 x 5=0.040).
|
18496125 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
RGD |
Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats.
|
18790848 |
2008 |
|
Diastolic hypertension
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The rs11739136 KCNMB1 Glu65Lys polymorphism in the beta1 subunit of the Ca2+ and voltage-dependent potassium channel has, in some studies, been reported to associate with a protective effect on diastolic hypertension.
|
18854753 |
2008 |
|
Airway Obstruction
|
0.010 |
GeneticVariation
|
group |
LHGDN |
An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity.
|
18535015 |
2008 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
The C818T SNP and four other KCNMB1 variants were genotyped in two independent groups of African American asthmatics (n = 509) and tested for association with the pulmonary function measure--forced expiratory volume (FEV(1)) % of predicted value.
|
18535015 |
2008 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The C818T SNP and four other KCNMB1 variants were genotyped in two independent groups of African American asthmatics (n = 509) and tested for association with the pulmonary function measure--forced expiratory volume (FEV(1)) % of predicted value.
|
18535015 |
2008 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
CTD_human |
KCNMB1 is involved in calcium sensitivity and hypertension.
|
17700361 |
2007 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
KCNMB1 is involved in calcium sensitivity and hypertension.
|
17700361 |
2007 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
RGD |
Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats.
|
16814121 |
2006 |
|
Hypertensive disease
|
0.550 |
Biomarker
|
group |
BEFREE |
Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study.
|
15671602 |
2005 |